Avinash Khanna

Modulators Of Methyl Modifying Enzymes, Compositions And Uses Thereof

Application

#2019032 Oct 24, 2019

Filed

Apr 18, 2019

Inventor

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA) · Ludivine Moine (Cambridge, MA) · Jacob I. Stuckey (Framingham, MA)

Appl. No.

16/387851

Assignee

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA) · Ludivine Moine (Cambridge, MA) · Jacob I. Stuckey (Framingham, MA)

International Classification

C07D 405/14, C07D 405/12, A61P 35/00

Abstract

Provided are novel compounds of Formula (I):and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.

Lsd1 Inhibitors And Medical Uses Thereof

Application

#2019027 Sep 12, 2019

Filed

Oct 26, 2017

Inventor

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA)

Appl. No.

16/345011

Assignee

Constellation Pharmaceuticals, Inc. (Cambridge, MA)

International Classification

A61K 31/397, A61K 31/438, A61P 31/18, A61P 31/22, A61P 35/02

Abstract

Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.

Lsd1 Inhibitors And Medical Uses Thereof

Application

#2020030 Oct 1, 2020

Filed

Nov 1, 2019

Inventor

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA)

Appl. No.

16/671559

Assignee

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA)

International Classification

A61K 31/397, A61P 31/22, A61P 31/18, A61P 35/02, A61K 31/438, C07D 205/12, C07D 221/20, A61P 35/00

Abstract

Provided are novel compounds of Formula (I or Ia′): and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with LSD1. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I or Ia′), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with LSD1.

Modulators Of Methyl Modifying Enzymes, Compositions And Uses Thereof

Application

#2020031 Oct 8, 2020

Filed

Apr 23, 2020

Inventor

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA) · Ludivine Moine (Cambridge, MA) · Jacob I. Stuckey (Framingham, MA)

Appl. No.

16/856454

Assignee

Victor S. Gehling (Somerville, MA) · Avinash Khanna (Cambridge, MA) · Ludivine Moine (Cambridge, MA) · Jacob I. Stuckey (Framingham, MA)

International Classification

C07D 405/14, A61P 35/00, C07D 405/12

Abstract

Provided are novel compounds of Formula (I):and pharmaceutically acceptable salts thereof, which are useful for treating a variety of diseases, disorders or conditions, associated with methyl modifying enzymes. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I), pharmaceutically acceptable salts thereof, and methods for their use in treating one or more diseases, disorders or conditions, associated with methyl modifying enzymes.