Gordon Hughes

Synthesis Of Gon-4-Enes

Application

#4002746 Jan 11, 1977

Filed

Jan 15, 1964

Inventor

Gordon Alan Hughes (Wayne, PA) · Herchel Smith (Wayne, PA)

Appl. No.

4/337823

Assignee

Gordon Alan Hughes (Wayne, PA) · Herchel Smith (Wayne, PA)

International Classification

C07J 7100

U.S. Classification

424243

Abstract

1. A therapeutic composition having progestational activity comprising as active ingredient a 17-aliphatic carboxylic acid ester of 17. alpha. -ethynyl-18-methyl-19-nortestosterone and a pharmaceutical carrier for said compound.

Diagnostic Assay For Detecting And Monitoring Age Related And Noise Induced Hearing Loss

Application

#2009007 Mar 19, 2009

Filed

May 7, 2008

Inventor

Vincent K. Tuohy (Broadview Heights, OH) · Gordon B. Hughes (Chagrin Falls, OH)

Appl. No.

12/116555

Assignee

Vincent K. Tuohy (Broadview Heights, OH) · Gordon B. Hughes (Chagrin Falls, OH)

International Classification

G01N 33/53, G01N 33/564

U.S. Classification

435 792, 436506

Abstract

A method of detecting age related and/or noise induced hearing loss in a subject includes detecting in a biological sample from the subject the presence of cochlin antibodies; and correlating the level of detected cochlin antibodies to the presence or absence of age related and/or noise induced hearing loss in the subject.

Synthesis Of 13-Alkyl-Gon-4-Ones

Application

#3959322 May 25, 1976

Filed

Aug 11, 1964

Inventor

Gordon Alan Hughes (Wayne, PA) · Herchel Smith (Wayne, PA)

Appl. No.

4/388820

Assignee

Gordon Alan Hughes (Wayne, PA) · Herchel Smith (Wayne, PA)

International Classification

C07J 7100

U.S. Classification

2603974

Abstract

The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.

Systems And Methods For Detecting Image Recapture

Application

#2021030 Sep 30, 2021

Filed

Jun 14, 2021

Inventor

Justin Mark STAYTON (Chattanooga, TN) · Gordon Charles HUGHES (Loveland, OH)

Appl. No.

17/346821

Assignee

TruePic Inc. (La Jolla, CA)

International Classification

G06T 7/00, G06K 9/46, G06K 9/62

Abstract

Systems, computer-implemented methods, and non-transitory machine-readable storage media are provided for detecting recapture attacks of images. One method comprises extracting one or more features from an image captured by a device; applying the one or more features as input to a trained machine learning model, wherein the trained machine learning model outputs a first score based on the extracted features; obtaining metadata of the image; performing a statistical analysis of the metadata of the image; generating a second score based on the statistical analysis of the metadata of the image; and generating a probability that the image is a recapture of an original image based on the first score and the second score.

Cord Wood Rack And Carrier

Application

#4823965 Apr 25, 1989

Filed

Oct 27, 1987

Inventor

Gordon Hughes (Florence, OR)

Appl. No.

7/113001

Assignee

Gordon Hughes (Florence, OR)

International Classification

A47F 700

U.S. Classification

211 601

Abstract

A portable compactly stored cord rack and carrier assembly is set forth. A flexible wood carrier formed of canvas or leather-like material is provided with opposed handles at terminal ends thereof and supportably enables transport of firewood whereby the accompanying foldable rack provides cradled support thereof. Said rack comprises a scissor-like pair of pivoted framework members formed with flexible strap elements securing opposed horizontal structural portions for support and reinforcement of the firewood carrier.

Dithioketal Derivatives Of 13-Polycarbonalkylgon-4-En-3-O...

Application

#4005078 Jan 25, 1977

Filed

Jun 29, 1966

Inventor

Gordon Alan Hughes (Haverford, PA) · Herchel Smith (Wayne, PA)

Appl. No.

4/561365

Assignee

Gordon Alan Hughes (Haverford, PA) · Herchel Smith (Wayne, PA)

International Classification

C07J 3300

U.S. Classification

2602395

Abstract

Novel 3-thioketals of 13-polycarbonalkyl-17-ethynyl-17-hydroxygon-4-ene and 13-polycarbonalkyl-17-chlorethynyl-17-hydroxygon-4-ene, with improved separation of activities, i. e. maximizing progestational and minimizing androgenic action, are prepared from the corresponding 3-carbonyl compounds by treatment with dithioethylene ketal in the presence of an acid catalyst.