Michael Gladstone

Anti-Il-27 Antibodies And Uses Thereof

Application

#2019038 Dec 19, 2019

Filed

Mar 22, 2019

Inventor

Michael GLADSTONE (Cambridge, MA) · Bianka PRINZ (Lebanon, NH) · Andrew LAKE (Westwood, MA) · Christine MILLER (Amesbury, MA) · Kerry WHITE (Danvers, MA) · Jing HUA (Wellesley, MA) · Pamela M. HOLLAND (Belmont, MA) · Matthew RAUSCH (Cambridge, MA)

Appl. No.

16/362457

Assignee

Michael GLADSTONE (Cambridge, MA) · Bianka PRINZ (Lebanon, NH) · Andrew LAKE (Westwood, MA) · Christine MILLER (Amesbury, MA) · Kerry WHITE (Danvers, MA) · Jing HUA (Wellesley, MA) · Pamela M. HOLLAND (Belmont, MA) · Matthew RAUSCH (Cambridge, MA)

International Classification

C07K 16/24, A61K 45/06, A61K 39/395, G01N 33/68, A61P 35/00

Abstract

The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

Antibody Molecules To Cd73 And Uses Thereof

Application

#2023003 Feb 9, 2023

Filed

Mar 15, 2022

Inventor

Ansgar Brock (San Diego, CA) · Viviana Cremasco (Arlington, MA) · Glenn Dranoff (Sudbury, MA) · Scott Chappel (Cambridge, MA) · Andrew Lake (Cambridge, MA) · Alison Paterson (Cambridge, MA) · Rachel W. O'Connor (Cambridge, MA) · Michael Warren (Cambridge, MA) · Pamela Holland (Cambridge, MA) · Kulandayan Kasi Subramanian (Belmont, MA) · Dirksen Bussiere (Emeryville, CA) · Mikias Woldegiorgis (Oakland, CA) · Wei Shu (Danville, CA) · Michael Gladstone (Cambridge, MA) · Jonathan Hill (Cambridge, MA) · Christine Miller (Cambridge, MA)

Appl. No.

17/695267

Assignee

Ansgar Brock (San Diego, CA) · Viviana Cremasco (Arlington, MA) · Glenn Dranoff (Sudbury, MA) · Scott Chappel (Cambridge, MA) · Andrew Lake (Cambridge, MA) · Alison Paterson (Cambridge, MA) · Rachel W. O'Connor (Cambridge, MA) · Michael Warren (Cambridge, MA) · Pamela Holland (Cambridge, MA) · Kulandayan Kasi Subramanian (Belmont, MA) · Dirksen Bussiere (Emeryville, CA) · Mikias Woldegiorgis (Oakland, CA) · Wei Shu (Danville, CA) · Michael Gladstone (Cambridge, MA) · Jonathan Hill (Cambridge, MA) · Christine Miller (Cambridge, MA)

International Classification

C07K 16/28, A61K 39/395, A61K 31/495, A61K 39/40, A61P 35/00, A61K 45/06, G01N 33/68

Abstract

Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.

Regulated Biocircuit Systems

Application

#2019019 Jun 27, 2019

Filed

Apr 11, 2017

Inventor

Michael N. Gladstone (Cambridge, MA) · Tariq A. Kassum (Cambridge, MA) · Vipin Suri (Belmont, MA) · Dan Jun Li (Cambridge, MA) · Dexue Sun (Cambridge, MA) · Brian Dolinski (Cambridge, MA)

Appl. No.

16/092829

Assignee

Michael N. Gladstone (Cambridge, MA) · Tariq A. Kassum (Cambridge, MA) · Vipin Suri (Belmont, MA) · Dan Jun Li (Cambridge, MA) · Dexue Sun (Cambridge, MA) · Brian Dolinski (Cambridge, MA)

International Classification

A61K 48/00, A61K 35/17, A61P 3/08, C07K 14/605, C12N 15/11, C12N 9/22, C12N 5/0789, C07K 14/195, C07K 14/54, C12N 9/00, C07K 16/28, C07K 14/705, C07K 14/725

Abstract

The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.

Anti-Il-27 Antibodies And Uses Thereof

Application

#2023004 Feb 9, 2023

Filed

Apr 6, 2022

Inventor

Michael GLADSTONE (Cambridge, MA) · Bianka PRINZ (Lebanon, NH) · Andrew LAKE (Westwood, MA) · Christine MILLER (Amesbury, MA) · Kerry WHITE (Danvers, MA) · Jing HUA (Wellesley, MA) · Pamela M. HOLLAND (Belmont, MA) · Matthew RAUSCH (Cambridge, MA)

Appl. No.

17/714942

Assignee

Surface Oncology, Inc. (Cambridge, MA) · Adimab LLC (Lebanon, NH)

International Classification

C07K 16/24, A61P 35/00, A61K 39/395, A61K 45/06, G01N 33/68

Abstract

The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

Pde5 Compositions And Methods For Immunotherapy

Application

#2020010 Apr 2, 2020

Filed

Jun 12, 2018

Inventor

Byron DELABARRE (Arlington, MA) · Michael N. GLADSTONE (Cambridge, MA) · Celeste RICHARDSON (Brookline, MA) · Brian DOLINSKI (Cambridge, MA) · Abhishek KULKARNI (Brookline, MA) · Mara Christine INNISS (Beverly, MA) · Dexue SUN (Cambridge, MA) · Dan Jun LI (Cambridge, MA) · Grace Y. OLINGER (Cambridge, MA) · Scott Francis HELLER (Stoughton, MA)

Appl. No.

16/621593

Assignee

Byron DELABARRE (Arlington, MA) · Michael N. GLADSTONE (Cambridge, MA) · Celeste RICHARDSON (Brookline, MA) · Brian DOLINSKI (Cambridge, MA) · Abhishek KULKARNI (Brookline, MA) · Mara Christine INNISS (Beverly, MA) · Dexue SUN (Cambridge, MA) · Dan Jun LI (Cambridge, MA) · Grace Y. OLINGER (Cambridge, MA) · Scott Francis HELLER (Stoughton, MA)

International Classification

A61K 38/46, C07K 16/28, C07K 14/725, A61K 35/17, A61P 35/00, C12N 9/16, C07K 14/705, C07K 14/715, C07K 14/54, A61K 31/4985, A61K 39/395, A61K 38/17, A61K 38/20

Abstract

The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.

Antibody Molecules To Cd73 And Uses Thereof

Application

#2021021 Jul 15, 2021

Filed

May 30, 2019

Inventor

Glenn Dranoff (Sudbury, MA) · Kulandayan Kasi Subramanian (Belmont, MA) · Bianka Prinz (Lebanon, NH) · Jerry M. Thomas (Lebanon, NH) · Andrew Lake (Cambridge, MA) · Scott Chappel (Cambridge, MA) · Pamela Holland (Cambridge, MA) · Michael Warren (Cambridge, MA) · Alison Paterson (Cambridge, MA) · Rachel W. O'Connor (Cambridge, MA) · Michael Gladstone (Cambridge, MA) · Jonathan Hill (Cambridge, MA) · Christine Miller (Cambridge, MA)

Appl. No.

17/059056

Assignee

Glenn Dranoff (Sudbury, MA) · Kulandayan Kasi Subramanian (Belmont, MA) · Bianka Prinz (Lebanon, NH) · Jerry M. Thomas (Lebanon, NH) · Andrew Lake (Cambridge, MA) · Scott Chappel (Cambridge, MA) · Pamela Holland (Cambridge, MA) · Michael Warren (Cambridge, MA) · Alison Paterson (Cambridge, MA) · Rachel W. O'Connor (Cambridge, MA) · Michael Gladstone (Cambridge, MA) · Jonathan Hill (Cambridge, MA) · Christine Miller (Cambridge, MA)

International Classification

C07K 16/28, G01N 33/573

Abstract

Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.