Peter Boxer

Composition And Method Of Treating Temporary And Permanent Hearing Loss

Application

#2009015 Jun 18, 2009

Filed

Nov 21, 2008

Inventor

Josef M. Miller (Ann Arbor, MI) · Colleen G. Le Prell (Gainesville, FL) · D. Clark Bennett (Portage, MI) · Peter A. Boxer (Dexter, MI)

Appl. No.

12/313527

Assignee

Josef M. Miller (Ann Arbor, MI) · Colleen G. Le Prell (Gainesville, FL) · D. Clark Bennett (Portage, MI) · Peter A. Boxer (Dexter, MI)

International Classification

A61K 33/00

U.S. Classification

424722

Abstract

A composition for treating permanent and temporary hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.

Use Of Matrix Metalloproteinase Inhibitors For Treating Neurological Disorders And Promoting Wound Healing

Application

#6340709 Jan 22, 2002

Filed

Mar 19, 1999

Inventor

Thomas Michael Andrew Bocan (Ann Arbor, MI) · Peter Alan Boxer (Ann Arbor, MI) · Denis Schrier (Ann Arbor, MI) · Andrew David White (Pinckney, MI)

Appl. No.

09/269123

Assignee

Warner-Lambert Company (Morris Plains, NJ)

International Classification

A61K 3118

U.S. Classification

514602, 514600, 514601

Abstract

This invention provides a method for treating and preventing neurological disorder such as Alzheimers disease, and for promoting wound healing comprising administering a compound characterized as being a matrix metalloproteinase inhibitor.

Claim

What is claimed is: 1. A method for treating a neurological disorder in a mammal, comprising: administering to a mammal in need thereof an effective amount of a matrix metalloproteinase inhibitor, wherein the MMP inhibitor utilized is a compound of the formula wherein: R1 is C1-C6 allyl, halo, nitro, NR4R5, cyano, OR4, and COOR4; R2 is C1-C6 alkyl, optionally substituted by phenyl, substituted phenyl, NR4R5, OR6, carboxy, carboxamido,  thio, methylthio, indole, imidazole, phthalimido, phenyl, and substituted phenyl; R3 is OH, OC1-C6 alkyl, or NHOH; R4 is hydrogen, C1-C6 alkyl, or C1-C6 alkanoyl; R5 is hydrogen or C1-C6 alkyl; and R6 is hydrogen, C1-C6 alkyl, C1-C6 alkanoyl, phenyl, or substituted phenyl. 2. The method of claim 1 wherein the neurological disorder is Alzheimer's disease. 3. The method of claim 1 wherein the neurological disorder is Huntington's disease. 4.