Nicole Parrish

Antimicrobial Compounds

Application

#6713654 Mar 30, 2004

Filed

Aug 28, 2000

Inventor

Craig A. Townsend (Baltimore, MD) · James D. Dick (Upperco, MD) · Gary R. Pasternack (Baltimore, MD) · Francis P. Kuhajda (Lutherville, MD) · Nicole M. Parrish (Ellicott City, MD)

Appl. No.

09/486550

Assignee

The Johns Hopkins University School of Medicine (Baltimore, MD)

International Classification

C07C31500

U.S. Classification

568 27, 568 28, 568 31

Abstract

This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula RâSO âZâCOâY, where R is an alkyl group having 6-20 carbons; Z is a radical selected from âCH â, âOâ, and âNHâ, two of these radicals coupled together, or âCH CH â; Y is âNH , OâCH âC H , âCOâCOâOâCH , or OâCH ; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize -substitued, -hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as drug-resistant and.

Claim

What is claimed is: 1. A compound of formula R—SOn—Z—CO—Y wherein, R is an alkyl group having 6-20 carbon atoms; Z is a radical selected from the group consisting of —CH2—, —O—, —CH2—NH—, —CH2—O—, —O—CH2—, and —NH—CH2—; Y is selected from the group consisting of —NH2, —O—CH2—C6H5, and —CO—CO—O—CH3; and n is 1 or 2. 2. A compound according to claim 1, wherein R is an n-alkyl group. 3. A compound according to claim 1, wherein n is 1. 4. A compound according to claim 1, wherein n is 2. 5. A compound according to claim 1, wherein Z is —CH2—. 6. A compound according to claim 1, wherein Y is —NH2. 7. A compound according to claim 1, wherein R is a branched alkyl group. 8.

Antimicrobial Compounds

Application

#7385086 Jun 10, 2008

Filed

Jan 27, 2004

Inventor

Craig A. Townsend (Baltimore, MD) · James D. Dick (Upperco, MD) · Gary R. Pasternack (Baltimore, MD) · Francis P. Kuhajda (Lutherville, MD) · Nicole M. Parrish (Ellicott City, MD)

Appl. No.

10/764451

Assignee

The Johns Hopkins University School of Medicine (Baltimore, MD)

International Classification

C07C 317/00, C07C 317/02, C07C 317/04, C07C 317/06, C07C 317/08

U.S. Classification

568 27, 568 28, 568 31, 514550, 514618

Abstract

This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SO-Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH—, —CHCH—, —NH—NH—, —O—, ——NH—, —O—NH—, —CH—NH—, —CH—O—, —NH—O—, —NH—CH—, —O—CH—, and —CH═CH—; Y is —NH, —O—CH—CH, —CO—CO—O—CH, and —O—CH; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as , drug resistant , and pathogenic sp.

Anti-Mycobacterial Formulation

Application

#2007024 Oct 18, 2007

Filed

Feb 8, 2007

Inventor

Nicole Parrish (Ellicott City, MD) · Albert Owens (Bel Air, MD) · James Dick (Upperco, MD)

Appl. No.

11/672909

Assignee

FASgen Inc. (Baltimore, MD)

International Classification

A61K 31/165, C07C 233/05, C12N 1/20, C12N 1/38

U.S. Classification

514625000, 435243000, 435253100, 564192000

Abstract

The invention provides anti-microbial compositions, including compositions with inhibitory activity against mycobacteria. The invention further provides methods for treating microbial infections, including the treatment of mycobacterial infection and diseases such as tuberculosis.

Methods Of Treating Microbial Infections In Humans And Animals

Application

#2006013 Jun 22, 2006

Filed

Jul 9, 2003

Inventor

Craig Townsend (Baltimore, MD) · James Dick (Baltimore, MD) · Nicole Parrish (Ellicott City, MD) · Minerva Hughes (Baltimore, MD)

Appl. No.

10/520506

Assignee

Craig Townsend (Baltimore, MD) · James Dick (Baltimore, MD) · Nicole Parrish (Ellicott City, MD) · Minerva Hughes (Baltimore, MD)

International Classification

A61K 31/455, A61K 31/421, A61K 31/381, A61K 31/365, A61K 31/16, A61K 31/22

U.S. Classification

514355000, 514374000, 514445000, 514471000, 514550000, 514614000

Abstract

A method of treating a subject with a microbially-based infection, comprising the administration of a compound to the subject. The compound is able to decrease ATP levels in the microbe by at least 10% compared to controls after 24 hours in an in vitro test, without killing mammalian cells during the same time period. The decrease in ATP levels is measured by: (1) removing the cells from the testing location and putting them on ice; (2) harvesting the cells at 4 degrees C. by centrifugation and disrupting it with bead-beating in an ATP extraction buffer; (3) removing cellular debris by centrifugation at 4 degrees C., leaving an ATP-containing supernatant; (4) measuring the amount of ATP present in the supernatant by a bioluminescence assay at 4 degrees C.