University Florida

Sol-Gel Derived Bioactive Glass Polymer Composite

Application

#2013009 Apr 18, 2013

Filed

Nov 30, 2012

Inventor

Anthony Brennan (Gainesville, FL) · Brian Cuevas (Gainesville, FL) · Charles Seegert (Gainesville, FL)

Appl. No.

13/690538

Assignee

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, FL)

International Classification

A61K 47/00, A61K 47/32, A61K 47/24, A61K 47/02

U.S. Classification

424400, 514769

Abstract

A bioactive sol-gel solution includes a biocompatible polymer, a gelable inorganic base material, and at least one calcium and phosphorous molecular species. The base material can be an alkoxide, such as TEOS. The polymer acts as a viscosity modifier to the sol or gel, increases the viscosity range over which fibers can be sprayed or spun, and broadens the time period over which fibers can be sprayed or spun. A bioactive glass composite can be formed from the bioactive sol-gel solution, including a fibrous form. Fibers can serve as a scaffolds for cell growth and in the repair of hard or soft tissue defects.

Multimodal Nanoparticles For Non-Invasive Bio-Imaging

Application

#2013012 May 23, 2013

Filed

Dec 28, 2012

Inventor

BRIJ M. MOUDGIL (GAINESVILLE, FL) · GLENN A. WALTER (NEWBERRY, FL) · STEPHEN R. GROBMYER (SHAKER HEIGHTS, OH) · SWADESHMUKUL SANTRA (ORLANDO, FL) · HUABEI JIANG (GAINESVILLE, FL) · SCOTT CHANG BROWN (HOCKESSIN, DE) · EDWARD W. SCOTT (GAINESVILLE, FL) · QIZHI ZHANG (GAINESVILLE, FL) · NICLAS BENGTSSON (LAKE FOREST PARK, WA)

Appl. No.

13/729815

Assignee

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (GAINESVILLE, FL)

International Classification

A61K 49/22, A61M 31/00, A61N 5/10, A61K 41/00

U.S. Classification

424 932, 424 942, 424 96, 600431, 600411

Abstract

Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

Vestibular Dynamic Inclinometer

Application

#2013015 Jun 20, 2013

Filed

Oct 31, 2012

Inventor

Vishesh Vikas (Cambridge, MA)

Appl. No.

13/665872

Assignee

University of Florida Research Foundation, Inc. (Gainesville, FL)

International Classification

G06F 17/00, G01C 9/02

U.S. Classification

702141

Abstract

A method of determining orientation parameters of a rigid body (), including: associating at least two multi-axis accelerometers () with the rigid body, wherein the body has a base end ), a distal end (), and a line of symmetry between the base end and the distal end. The two first multi-axis accelerometers () () are disposed at a first point () along the line of symmetry between the base end and the distal end. Each first multi-axis accelerometer is disposed at equal distances from the line of symmetry. The line of symmetry and both first multi-axis accelerometers lie in a first plane. The method further includes: associating a gyroscope () with the body at the first point, equally between both first multi-axis accelerometers; gathering measured data from the two first multi-axis accelerometers and the gyroscope; and applying analysis free of calculus to determine a first inclination angle () (), of the body from a stable orientation.

Transduction Efficiency, Capsid-Modified Raav Vectors And Methods Of Use

Application

#2013020 Aug 8, 2013

Filed

Apr 2, 2013

Inventor

Sergei Zolotukhin (Gainesville, FL) · Lakshmanan Govindasamy (Gainesville, FL) · Arun Srivastava (Gainesville, FL)

Appl. No.

13/855640

Assignee

University of Florida Research Foundation, Inc. (Gainesville, FL)

International Classification

A61K 48/00

U.S. Classification

514 44 R, 4353201

Abstract

Disclosed are tyrosine-modified rAAV vectors, as well as infectious virions, compositions, and pharmaceutical formulations that comprise them. Also disclosed are methods of preparing and methods for using the disclosed tyrosine-phosphorylated capsid protein mutant rAAV vectors in a variety of diagnostic and therapeutic applications including in vivo and ex vivo gene therapy, and large-scale production of rAAV vectors.

Method, System, And Apparatus For Clinical Trial Management Over A Communications Network

Application

#2013008 Mar 28, 2013

Filed

Nov 15, 2012

Inventor

Michael Conlon (Gainesville, FL) · Phillip Padgett (Gainesville, FL)

Appl. No.

13/678144

Assignee

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, FL)

International Classification

G06Q 50/22

U.S. Classification

705 2

Abstract

A centralized, online clinical study system configured to coordinate aspects of a clinical study can include a training module configured to evaluate whether users have completed training for selected workflows for the clinical study that are available from the clinical study system, and to provide training to registered users for the selected workflows. The system also can include a financial engine configured to determine when a participating site meets or exceeds a milestone of the clinical study and to initiate a payment to the participating site. Further, the system can include a module configured to receive and verify clinical research data and to designate the verified clinical research data as official source data for the clinical study.

System And Method For Assessing The Performance Of An Attitude Control System For Small Satellites

Application

#2013012 May 23, 2013

Filed

Jan 14, 2013

Inventor

Vivek Nagabhushan (Gainesville, FL)

Appl. No.

13/740728

Assignee

UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (Gainesville, FL)

International Classification

G01L 3/00, B64F 5/00

U.S. Classification

73862041

Abstract

Various embodiments of the present invention include systems and methods for assessing the performance of an actuator of an attitude control system (ACS), such as a control moment gyroscope (CMG). In one embodiment, a system includes a support bracket assembly coupled to an actuator, wherein the actuator is configured to generate an output torque. The system also includes at least one sensor assembly that includes a sensor configured to measure the output torque about at least one axis of the support bracket assembly while the support bracket assembly remains substantially motionless.